The ING tumor suppressors in cellular senescence and chromatin

Tumour suppressors and cellular senescence.

Cellular senescence is a stable cell cycle arrest that normal cells undergo in response to a variety of intrinsic and extrinsic stimuli, including progressive telomere shortening, changes in telomeric structure or other forms of genotoxic as well nongenotoxic stress. Senescence is thought to have originated as a remodelling program that is active in embryonic development and acts as a key tumou...

Role of ING Family Tumor Suppressors in Breast Cancer

Chromatin remodeling, BRCA1, SAHF and cellular senescence

Cellular senescence is a state of stable cell growth arrest. Activation of oncogenes in primary mammalian cells typically triggers cellular senescence. Oncogeneinduced senescence is an important tumor suppression mechanism, driving stable growth arrest of cancer progenitor cells harboring the initial oncogenic hit. Chromatin in the nuclei of senescent human cells is often reorganized to form sp...

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3

Activation of a cellular senescence program is a common response to prolonged oncogene activation or tumor suppressor loss, providing a physiological mechanism for tumor suppression in premalignant cells. The link between senescence and tumor suppression supports the hypothesis that a loss-of-function screen measuring bona fide senescence marker activation should identify candidate tumor suppre...

Molecular and Cellular Pathobiology Contrasting Behavior of the p18 and p16 Tumor Suppressors in Both Replicative and Oncogene-Induced Senescence

The cyclin-dependent kinase (CDK) inhibitors, p18 and p16, both have the credentials of tumor suppressors in human cancers andmousemodels. For p16, the underlying rationale is its role in senescence, but the selective force for inactivation of p18 in incipient cancer cells is less clear. Here, we show that in human fibroblasts undergoing replicative or oncogene-induced senescence, there is amar...